Combination empirical antimicrobial therapy, including agents that target Gram-negative bacteria, have been reported to lower mortality and morbidity in patients with severe sepsis. Investigators from the German-based SepNet trials group performed a randomized, open-label, parallel-group study to compare the effect of combination therapy with meropenem and moxifloxacin (combination therapy) versus meropenem alone (monotherapy) for empirical [...]