Epinephrine for Cardiac Arrest

17 Apr

Posted by SCCM as Concise Critical Appraisal

For more than 40 years, epinephrine has been regarded as a standard of care in advanced cardiac life support. In the March 21 issue of The Journal of the American Medical Association, Hagihara et al performed the largest prospective, nonrandomized observational study to date to determine how epinephrine use in cardiopulmonary resuscitation before hospital arrival was [...]

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Effects of Amantadine for Severe Traumatic Brain Injury

02 Apr

Posted by SCCM as Concise Critical Appraisal

Limited observational data have suggested that amantadine, an indirect dopamine agonist and N-methyl-D-aspartate antagonist, may have favorable neurobehavioral effects for patients with severe traumatic brain injury (TBI). The favorable effects may be due to enhanced neurotransmission during a period of dopamine depletion and neuronal hypoexcitability following brain injury. In the March issue of The New [...]