Risk for Inadvertent Discontinuation of Chronic Medications after ICU Admissions

15 Sep

Posted by SCCM as Concise Critical Appraisal

Intensive care unit (ICU) admissions may lead to unintentional discontinuation of long-standing, evidence-based drug therapies. In the August issue of the Journal of the American Medical Association, Bell et al conducted a population-based cohort study in Ontario, Canada, to investigate whether ICU or hospital admissions were associated with a greater risk for inadvertent discontinuation of long-term medications. A [...]

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Antibiotics in Septic Shock: Is Time Really of the Essence?

01 Sep

Posted by SCCM as Concise Critical Appraisal

The Surviving Sepsis Campaign guidelines recommend initiating broad-spectrum antibiotics within one hour to treat severe sepsis or septic shock. In September’s Critical Care Medicine, Puskarich et al studied the association between time to initial antibiotic administration and in-hospital mortality rates for septic patients treated with the quantitative resuscitation protocol. The study design was a preplanned [...]